p53 Regulates the Expression of the Tumor Suppressor Gene Maspin
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چکیده
منابع مشابه
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.
Tumorigenesis is associated with enhanced cellular glucose uptake and increased metabolism. Because the p53 tumor suppressor is mutated in a large number of cancers, we evaluated whether p53 regulates expression of the GLUT1 and GLUT4 glucose transporter genes. Transient cotransfection of osteosarcoma-derived SaOS-2 cells, rhabdomyosarcoma-derived RD cells, and C2C12 myotubes with GLUT1-P-Luc o...
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Yutaka MAEDA*1,2, Wendy W. HWANG-VERSLUES†1, Gang WEI‡3, Takuya FUKAZAWA§4, Mary L. DURBIN¶5, Laurie B. OWEN§6, Xuan LIU‡ and Frances M. SLADEK*7 *Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, U.S.A., †Environmental Toxicology Graduate Program, University of California, Riverside, CA 92521, U.S.A., ‡Department of Biochemistry, University of Californ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2000
ISSN: 0021-9258
DOI: 10.1074/jbc.275.9.6051